Johann S de Bono Selected Research

Prednisone (Sone)

1/2022	Pembrolizumab Plus Docetaxel and Prednisone in Patients with Metastatic Castration-resistant Prostate Cancer: Long-term Results from the Phase 1b/2 KEYNOTE-365 Cohort B Study.
1/2020	Cabozantinib for Progressive Metastatic Castration-resistant Prostate Cancer Following Docetaxel: Combined Analysis of Two Phase 3 Trials.
1/2019	Cabozantinib Versus Mitoxantrone-prednisone in Symptomatic Metastatic Castration-resistant Prostate Cancer: A Randomized Phase 3 Trial with a Primary Pain Endpoint.
1/2018	Antitumour Activity and Safety of Enzalutamide in Patients with Metastatic Castration-resistant Prostate Cancer Previously Treated with Abiraterone Acetate Plus Prednisone for ≥24 weeks in Europe.
1/2017	Custirsen in combination with docetaxel and prednisone for patients with metastatic castration-resistant prostate cancer (SYNERGY trial): a phase 3, multicentre, open-label, randomised trial.
1/2017	Clinical Outcomes from Androgen Signaling-directed Therapy after Treatment with Abiraterone Acetate and Prednisone in Patients with Metastatic Castration-resistant Prostate Cancer: Post Hoc Analysis of COU-AA-302.
1/2016	Low Incidence of Corticosteroid-associated Adverse Events on Long-term Exposure to Low-dose Prednisone Given with Abiraterone Acetate to Patients with Metastatic Castration-resistant Prostate Cancer.
10/2015	Impact of bone-targeted therapies in chemotherapy-naïve metastatic castration-resistant prostate cancer patients treated with abiraterone acetate: post hoc analysis of study COU-AA-302.
5/2015	Impact of baseline corticosteroids on survival and steroid androgens in metastatic castration-resistant prostate cancer: exploratory analysis from COU-AA-301.
4/2015	Improvements in Radiographic Progression-Free Survival Stratified by ERG Gene Status in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Abiraterone Acetate.

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Johann S de Bono Research Topics

Disease

199	Prostatic Neoplasms (Prostate Cancer) 05/2024 - 12/2005
121	Neoplasms (Cancer) 04/2024 - 01/2002
24	Disease Progression 11/2023 - 08/2009
22	Circulating Neoplastic Cells 05/2021 - 06/2007
19	Neoplasm Metastasis (Metastasis) 11/2023 - 04/2009
17	Fatigue 11/2020 - 05/2006
10	Ovarian Neoplasms (Ovarian Cancer) 02/2024 - 05/2010
10	Pain (Aches) 01/2020 - 09/2012
9	Carcinogenesis 05/2024 - 08/2009
8	Hypertension (High Blood Pressure) 01/2022 - 04/2008
7	Breast Neoplasms (Breast Cancer) 11/2023 - 01/2003
7	Nausea 01/2022 - 10/2007
6	Hyperglycemia 11/2014 - 10/2007
5	Genomic Instability 01/2021 - 01/2010
5	Vomiting 04/2020 - 02/2010
5	Diarrhea 04/2020 - 10/2007
5	Hypokalemia 10/2013 - 10/2008
4	Exanthema (Rash) 11/2023 - 11/2014
4	Neutropenia 01/2022 - 09/2011
4	Adenocarcinoma 01/2022 - 11/2004
4	Thrombocytopenia (Thrombopenia) 01/2022 - 10/2013
4	Carcinoma (Carcinomatosis) 01/2022 - 06/2007
4	Melanoma (Melanoma, Malignant) 10/2017 - 02/2007
3	Ataxia Telangiectasia (Louis Bar Syndrome) 05/2024 - 01/2021
3	Inflammation (Inflammations) 11/2023 - 11/2014
3	Anemia 10/2022 - 10/2015
3	Triple Negative Breast Neoplasms 01/2022 - 12/2011
3	Colorectal Neoplasms (Colorectal Cancer) 01/2019 - 01/2002
3	Cancer Pain 01/2017 - 01/2013
3	Anorexia 03/2010 - 10/2007
2	Lymphoma (Lymphomas) 01/2022 - 12/2011

Drug/Important Bio-Agent (IBA)

50	Androgen Receptors (Androgen Receptor)IBA 02/2024 - 08/2008
41	Biomarkers (Surrogate Marker)IBA 01/2023 - 06/2007
34	abirateroneIBA 11/2023 - 11/2008
33	enzalutamideIBA 11/2023 - 12/2009
33	Abiraterone AcetateIBA 11/2023 - 10/2008
31	Docetaxel (Taxotere)FDA Link 03/2024 - 03/2010
27	AndrogensIBA 11/2022 - 08/2008
24	Poly(ADP-ribose) Polymerase InhibitorsIBA 05/2024 - 01/2010
23	Hormones (Hormone)IBA 01/2024 - 06/2007
21	Prostate-Specific Antigen (Semenogelase)IBA 01/2022 - 04/2009
20	Prednisone (Sone)FDA LinkGeneric 01/2022 - 03/2010
19	DNA (Deoxyribonucleic Acid)IBA 11/2023 - 01/2003
13	olaparibIBA 11/2023 - 07/2009
12	Proteins (Proteins, Gene)FDA Link 01/2023 - 10/2008
11	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 09/2023 - 07/2009
10	PlatinumIBA 02/2024 - 05/2010
9	LigandsIBA 01/2022 - 10/2008
8	AntigensIBA 04/2024 - 12/2011
7	taxaneIBA 10/2021 - 10/2003
7	Monoclonal AntibodiesIBA 01/2014 - 11/2004
7	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA 04/2011 - 08/2008
6	Carboplatin (JM8)FDA LinkGeneric 01/2020 - 12/2011
6	Cell-Free Nucleic AcidsIBA 12/2018 - 01/2012
5	cabazitaxel FDA Link 01/2022 - 06/2011
5	Messenger RNA (mRNA)IBA 01/2022 - 11/2012
5	Phosphotransferases (Kinase)IBA 01/2020 - 09/2010
5	Testosterone (Sustanon)FDA Link 01/2019 - 08/2008
5	Insulin-Like PeptidesIBA 01/2014 - 06/2007
5	figitumumabIBA 01/2014 - 06/2007
4	Protein Isoforms (Isoforms)IBA 02/2024 - 09/2017
4	pembrolizumabIBA 11/2023 - 01/2022
4	EnzymesIBA 01/2023 - 01/2011
4	RNA (Ribonucleic Acid)IBA 12/2022 - 01/2003
4	Prednisolone (Predate)FDA LinkGeneric 01/2022 - 01/2017
4	SteroidsIBA 01/2022 - 12/2005
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2020 - 02/2015
4	cabozantinibIBA 01/2020 - 10/2014
4	Alkaline PhosphataseIBA 01/2020 - 04/2008
4	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 05/2015 - 01/2002
4	MK 2206IBA 02/2015 - 12/2011
3	Adrenal Cortex Hormones (Corticosteroids)IBA 03/2022 - 05/2015
3	Transcription Factors (Transcription Factor)IBA 01/2022 - 01/2018
3	Hemoglobins (Hemoglobin)IBA 01/2020 - 11/2014
3	Paclitaxel (Taxol)FDA LinkGeneric 01/2020 - 01/2014
3	Narcotics (Narcotic Analgesics)IBA 01/2019 - 10/2014
3	2- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidineIBA 01/2019 - 01/2015
3	Amino Acids FDA Link 10/2017 - 11/2015
3	Adenosine Diphosphate Ribose (ADP-Ribose)IBA 09/2016 - 07/2009
3	Androgen Antagonists (Antiandrogens)IBA 01/2015 - 01/2011
3	Histone Deacetylase InhibitorsIBA 10/2013 - 10/2008
3	MineralocorticoidsIBA 05/2011 - 10/2008
3	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 03/2010 - 10/2007
2	177Lu-PSMA-617IBA 01/2024 - 01/2022
2	BCL2-associated athanogene 1 proteinIBA 11/2023 - 10/2017
2	Thromboplastin (Tissue Factor)IBA 01/2023 - 01/2020
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2022 - 12/2011
2	TensinsIBA 12/2022 - 12/2011
2	talazoparibIBA 10/2022 - 01/2021
2	Nuclear Proteins (Protein, Nuclear)IBA 01/2022 - 04/2020
2	molibresibIBA 01/2022 - 04/2020

Therapy/Procedure

152	Castration 05/2024 - 08/2008
84	Therapeutics 05/2024 - 01/2002
41	Drug Therapy (Chemotherapy) 01/2023 - 06/2007
8	Radiotherapy 01/2022 - 05/2013
7	Precision Medicine 01/2022 - 09/2009
3	Immunotherapy 04/2024 - 01/2019
3	Aftercare (After-Treatment) 01/2019 - 01/2017
2	Duration of Therapy 10/2022 - 01/2016
2	Drug Tapering 01/2022 - 10/2013